Mi foto
Nombre: Entamoeba histolytica

Integrantes : Ignacio Díaz Stevenson, Carola Espinosa, Loreto García Fuentes, Carla Torres Godoy. Tecnología Médica. Universidad Nacional Andrés Bello.

martes, junio 20, 2006

Introducción


La amibiasis es la infección del intestino grueso causado por Entamoeba histolytica en el hombre. Es uno de los eucariotes más primitivos (protozoo), perteneciente a la familia Entamoibidae del orden Amoebida. Varias especias de amibas pueden habitar el tracto intestinal pero de ellas sólo E.histolytica puede ser patógena.Existen en el colon de dos formas: el trofozoíto o forma vegetativa lábil (no disemina la infección) y el quiste infectante (sobrevive fuera del hospedero por días o semanas ya sea a temperaturas bajas y humedad). También existe el prequiste el cual se divide por fisión binaria para así formar el quiste maduro tetranucleado.
Es más frecuente en adultos (sin importar raza ni sexo), se desarrolla preferentemente en zonas tropicales, llegando a ser la tercera enfermedad parasitaria más importante en el mundo.
La infección es mucho más frecuente que la enfermedad. Sus manifestaciones pueden variar desde portadores asintomáticos a enfermedad de grado variable.
Los dos mayores síndromes clínicos de la amibiasis son: colitis amibiana y abscesos hepáticos.
La infección se inicia cuando se consumen alimentos y agua contaminada con quistes. Así el ciclo de vida del parásito es por lo tanto simple, con un quiste infeccioso y un trofozoíto invasivo.
Las lesiones patológicas en el colon incluyen ulceraciones del epitelio intestinal e invasión de la propia lámina basal por causa de los trofozoítos.
En la patogénesis de la amibiasis se requiere de la colonización del intestino, ruptura del sistema de defensa del moco, adherencia y lisis de las células epiteliales.
La adherencia, patogénesis y la actividad proteolítica son tres eventos claves en la destrucción del tejido del hospedero.

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